Jan Bakker Selected Research

Lactic Acid (Lactate)

1/2021	Clinical use of peripheral perfusion parameters in septic shock.
1/2021	Blood lactate levels in sepsis: in 8 questions.
1/2021	Low Microcirculatory Perfused Vessel Density and High Heterogeneity are Associated With Increased Intensity and Duration of Lactic Acidosis After Cardiac Surgery with Cardiopulmonary Bypass.
11/2020	Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial.
8/2020	A lactate-targeted resuscitation strategy may be associated with higher mortality in patients with septic shock and normal capillary refill time: a post hoc analysis of the ANDROMEDA-SHOCK study.
6/2020	Hypoxia-related parameters during septic shock resuscitation: Pathophysiological determinants and potential clinical implications.
4/2020	Diastolic shock index and clinical outcomes in patients with septic shock.
1/2020	Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial.
1/2020	Lactate: Where Are We Now?
1/2020	Acidosis predicts mortality independently from hyperlactatemia in patients with sepsis.

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Jan Bakker Research Topics

Disease

34	Critical Illness (Critically Ill) 01/2022 - 01/2007
29	Septic Shock (Toxic Shock Syndrome) 02/2022 - 01/2004
24	Shock 02/2022 - 01/2004
19	Sepsis (Septicemia) 01/2021 - 06/2003
10	COVID-19 01/2022 - 08/2020
7	Hemorrhage 01/2022 - 06/2003
7	Hypoxia (Hypoxemia) 01/2021 - 04/2008
7	Infections 01/2021 - 08/2004
7	Hypotension (Low Blood Pressure) 01/2021 - 01/2008
7	Hyperlactatemia 01/2021 - 09/2010
7	Acute Kidney Injury (Acute Renal Failure) 01/2020 - 01/2011
3	Respiratory Insufficiency (Respiratory Failure) 03/2021 - 01/2021
3	Cardiogenic Shock 01/2021 - 01/2019
3	Endotoxemia 01/2020 - 05/2004
3	Delirium 01/2019 - 10/2014
3	Brain Death (Brain Dead) 06/2011 - 02/2010
2	Respiratory Tract Infections (Respiratory Tract Infection) 10/2021 - 04/2014
2	Heart Failure 01/2021 - 01/2019
2	Heart Arrest (Cardiac Arrest) 01/2021 - 02/2014
2	Inflammation (Inflammations) 01/2021 - 12/2020
2	Lactic Acidosis 01/2021 - 05/2013
2	Brain Ischemia (Cerebral Ischemia) 02/2020 - 05/2016
2	Acidosis 01/2020 - 05/2013
2	Hypovolemia 08/2017 - 01/2015
2	Ventilator-Associated Pneumonia 12/2014 - 08/2011
2	Wounds and Injuries (Trauma) 03/2013 - 09/2011
1	Communicable Diseases (Infectious Diseases) 01/2022
1	Low Cardiac Output 01/2021
1	Patient-Ventilator Asynchrony 01/2021
1	Reperfusion Injury 01/2021
1	Right Ventricular Dysfunction 09/2020
1	Hypercapnia 09/2020
1	Deglutition Disorders (Dysphagia) 03/2020
1	Malnutrition (Nutritional Deficiencies) 03/2020
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2020
1	Obesity 01/2020
1	Hemorrhagic Shock 11/2019
1	Bradycardia 10/2019
1	Brain Injuries (Brain Injury) 09/2019
1	Hypertension (High Blood Pressure) 01/2019
1	Infarction (Infarctions) 05/2016
1	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 05/2016

Drug/Important Bio-Agent (IBA)

35	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 01/2008
6	Oxygen (Dioxygen)IBA 01/2021 - 04/2008
6	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2020 - 12/2013
4	Biomarkers (Surrogate Marker)IBA 03/2021 - 04/2012
4	Lipocalin-2IBA 11/2019 - 12/2010
3	9 alpha,11 alpha,15 alpha- trihydroxy- 16- phenoxy- 17,18,19,20- tetranorprosta- 4,5,13- trienoic acid (TPT)IBA 01/2021 - 02/2020
3	Hypnotics and Sedatives (Sedatives)IBA 01/2020 - 01/2008
3	Pharmaceutical PreparationsIBA 05/2004 - 06/2003
2	Topotecan (Hycamtin)FDA LinkGeneric 01/2021 - 12/2020
2	AlbuminsIBA 01/2021 - 01/2019
2	Carbon MonoxideIBA 01/2020 - 11/2019
2	Opioid Analgesics (Opioids)IBA 01/2020 - 04/2008
2	CarboxyhemoglobinIBA 01/2020 - 11/2019
2	CreatinineIBA 01/2019 - 04/2012
2	Glucose (Dextrose)FDA LinkGeneric 05/2016 - 01/2004
2	EndotoxinsIBA 01/2016 - 02/2010
2	AcidsIBA 02/2010 - 10/2009
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2004 - 01/2004
1	Hemoglobins (Hemoglobin)IBA 01/2022
1	pyrrolidin-3-yl-methanesulfonic acid (PMSA)IBA 01/2022
1	Dobutamine FDA LinkGeneric 01/2021
1	Dopamine (Intropin)FDA LinkGeneric 01/2021
1	Neuromuscular Blocking AgentsIBA 01/2021
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021
1	CatecholaminesIBA 01/2021
1	fibrin fragment D (D-dimer)IBA 09/2020
1	Pyruvic Acid (Pyruvate)IBA 06/2020
1	Midazolam (Versed)FDA LinkGeneric 01/2020
1	Starch (Cornstarch)IBA 11/2019
1	Polyethylene (Polythene)IBA 11/2019
1	BenzodiazepinesIBA 01/2019
1	TranscortinIBA 01/2019
1	Calcium Gluconate (CBG)IBA 01/2019
1	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2019
1	Vasopressins (Vasopressin)IBA 12/2017
1	esmolol (Brevibloc)FDA LinkGeneric 01/2016
1	Adrenergic Agents (Adrenergic Drugs)IBA 01/2016
1	Dexmedetomidine FDA Link 01/2016
1	Colloids (Colloid)IBA 12/2015

Therapy/Procedure

36	Resuscitation 02/2022 - 01/2008
16	Critical Care (Surgical Intensive Care) 01/2022 - 08/2004
12	Therapeutics 02/2022 - 01/2004
7	Length of Stay 01/2022 - 08/2004
7	Artificial Respiration (Mechanical Ventilation) 10/2021 - 01/2010
3	Extracorporeal Membrane Oxygenation 01/2020 - 09/2019
3	Early Goal-Directed Therapy 07/2018 - 01/2009
3	Mechanical Ventilators (Ventilator) 08/2011 - 04/2008
2	Cardiopulmonary Resuscitation (CPR) 06/2021 - 01/2021
2	Noninvasive Ventilation 01/2021 - 03/2014
2	Fluid Therapy (Oral Rehydration Therapy) 12/2015 - 02/2015
2	Continuous Renal Replacement Therapy 01/2015 - 12/2010
2	Intravenous Infusions 01/2008 - 01/2004
1	Airway Management 01/2022
1	Tracheostomy 01/2021
1	Cardiopulmonary Bypass (Heart-Lung Bypass) 01/2021
1	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2020
1	Positive-Pressure Respiration (Positive End-Expiratory Pressure) 01/2019
1	Early Ambulation 01/2019